Saughall Road in Blacon will be closed on Saturday, July 23, to allow council workers to remove trees which have been deemed unsafe.
The 11 Robinia trees have been identified as being unsafe due to declining crowns, stem and fungal decay.
The council's cabinet member for economic development and infrastructure Brian Clarke said: “For public health and safety the trees will be removed this weekend.”
There will be a temporary road closure on Saughall Road, Blacon during the work.
He added: “The trees will be replaced as soon as possible with an alternative appropriate species.”
Diversions will be in place during the work that is expected to last most of the day on Saturday 23 July, further work may be necessary on Sunday 24 July.
Access will be available for residents during the work.