The company had strongly backed the UK’s membership of the EU ahead of the June 23 referendum and will now assess the competitive impact of the result.
They said the UK decision to leave the European Union 'should be seen as a wake-up call for Europe and as a catalyst for change'.
A statement from the company - the biggest employer in North Wales - said: "We will work constructively with the UK government to minimise any impact on our operations.
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“Clearly we will continue to support our workforce and operate our UK facilities.
"We will study the longer-term consequences of this decision on the competitive environment.”
Airbus has previously warned that a UK exit from the EU would present long-term economic risks.
It had warned it would be forced to reconsider investment in the UK if economic conditions suffered as a result.Watch the moment the Cheshire West EU referendum count results are announced