Chester FC boss Steve Burr wants those players on the fringe of his squad to use the bank holiday weekend to force themselves into his starting line-up.
With Ross Hannah injured, Ben Heneghan suspended and doubts over Luke George, the prospect of two games in 48 hours will put further strain on the Blues, who don't have massive strength in depth.
Burr has the option to add to his squad before the transfer window closes on Tuesday thanks to the club's Crowdfunder appeal, however he believes it is right and fair that he gives opportunities to those who haven't featured much so far.
Michael Kay will make his first start of the season while Dale Tonge, George Thomson and Tom Peers will come into contention, and Kane Richards and Sam Hughes could also feature.
Having seen his side's unbeaten run ended with a 5-2 defeat at Woking last weekend, Burr has targeted six points from the games at Macclesfield Town on Saturday and at home to Guiseley AFC on Monday (both 3pm).
Burr said: "The transfer window closes next Tuesday and then it reopens a week later for emergency loans and this will enable us to look at bringing someone in but I must say I’ve been very pleased with the lads we have got, and that includes the ones who haven’t been in the team.
"The game at Woking showed what can happen with a suspension for Ben and Ross getting injured, but that presents the lads not in the team with opportunities and although disappointed, their attitudes have been great.
“Ross is probably going to be out for a couple of weeks and we’ve had it confirmed that Ben’s ban will be one game, but what that does is give opportunities to others and Michael Kay has been desperately waiting for his chance and now he’s got it.
“Tom Shaw will be available but we’ll have to see about Luke George. He’s been struggling with a badly bruised toe for a couple of weeks and it’s not clearing up but he was excellent at Woking for us."
Preview: Macclesfield Town v Chester FC
Last season the Silkmen exceeded all expectations, spending most of the campaign in the top five before wilting in the final few weeks to miss out on the play-offs.
Rhys Taylor, Scott Barrow and Waide Fairhurst are among those to have left for pastures new over the summer and it has been a tough start for John Askey's men.
Three defeats, one draw and one victory - the 2-1 home win against Welling United - mean Macc head into tomorrow's game in 18th position.
LOOK: Action from Chester FC's 3-1 loss at Macclesfield Town last season
Askey remains positive having taken encouragement from his side's performance in a 1-0 defeat at Eastleigh last weekend, particularly after being critical of them following a 5-3 defeat at Lincoln City.
With his team still to pick up a point on the road, the Macc legend has stressed the importance of them making Moss Ross a fortress.
"I thought against Eastleigh we show great character and battled hard and just when we had started to take the game to Eastleigh an error cost us dearly," said Askey.
"After two tough away trips, it is great to be back at the Moss Rose. I thought we were comfortable winners in our last home game against Welling and we want to carry on our impressive home form that served us so well last season.
"I think Chester will come and try to win the game, try to play football. But as we all know our home record is very good, we’ve still not lost at home yet and thats what we’ve got to do, we’ve got to make sure that when teams come there going to have to fight very hard to get anything, thats the main thing for us is to keep the home form as good as was it was last season."
Last term the Blues lost 3-1 at Moss Rose despite creating a host of chances and missing a penalty through Sean McConville. Fairhurst, now with Torquay United, scored twice for the Silkmen, including a sensational 30 yarder.
Preview: Chester FC v Guiseley AFC
Guiseley boss Mark Bower hopes his team's 4-0 defeat to Aldershot Town last time out acts as a 'wake-up call' for his players.
Wins over Altrincham and Kidderminster Harriers mean the Lions are nestled in mid-table after five games ahead of the visit of Gateshead on Saturday.
Bower’s side, promoted via the National League North play-offs, had started the brighter against the Shots but were put to the sword with two goals in either half.
"We’ve got to make sure this is a wake-up call," said Bower.
"We’ve had a few pats on the back in those first four games but we’ve got to make sure we react properly and learn lessons from it.
"We can’t overreact, we’ve got a good squad of players. We’ve got to utilise it well and bounce back from Saturday."
Last time the Blues hosted the Lions was in September 2013 when Neil Young's side thumped their rivals at the top-of-the-table 4-0 with Ben Mills scoring a hat-trick.
However, the teams met again later that season at Nethermoor with Guiseley running out 2-1 winners with two Josh Wilson goals cancelling out Tony Gray's strike.