Chester FC will match a feat dating back to the 1930s should Steve Burr's team win or draw at the Racecourse on Sunday.
It has been almost 80 years since the Blues last went through five consecutive cross-border derbies without defeat.
Charlie Sargeant's goal in a 1-1 draw at Sealand Road in January 1936 started an unbeaten sequence of six-matches, which include four victories.
Although Wrexham, who triumphed 3-2 in the first meeting between the clubs back in December 1888 at Faulkner Street, hold the upper hand in all-time results, recent history has favoured the Blues.
By the time Saturday comes around, it will have been more than 2,500 days since the Welsh club's last win over Chester.
Take a look back at what happened in the five most recent cross-border derbies in the gallery above.
Chester FC 2 Wrexham 1 (September 22, 2014)
Ben Heneghan’s last-gasp strike sealed an incredible win for the Blues in a game that will rank as one of the most memorable between the rivals.
Wrexham bossed the first period and could have been three or four up going into the break but had to make do with a one-goal lead thanks to Blaine Hudson.
Chester turned things around in the second, hitting the post and having a goal ruled out before Craig Hobson drew them level with a deft flick.
Wrexham looked to have survived the ensuing onslaught as the clock ticked down but Heneghan popped up with the winning goal in the dying seconds, sending the home fans wild.
Chester FC 0 Wrexham 0 (April 19, 2014)
Steve Burr experienced a frustrating first cross-border derby as his team struggled to break down a defensive-minded Wrexham outfit.
Chester had more possession, more chances and were the better team, although that didn't count for much in a game between two poor sides.
Scoring opportunities were few and far between, and the most controversial moment of the first-half came when Joe Anyinsah clattered Kevin McIntyre and could count himself fortunate to escape with just a booking.
Although the Blues, who were in desperate need of a win at the wrong end of the table, had the clearer openings, the Reds ended the game the stronger and might have nicked a win had Joe Clarke not shot straight at Aaron Chapman.
Wrexham 0 Chester FC 2 (August 31, 2014)
A brilliant team performance earned the Blues their first league win at the Racecourse since 1978 in the first meeting with Wrexham as a fan-owned club.
Chester made a dream start when captain Paul Linwood headed in a Jordan Laidler free kick after just four minutes, sparking jubilant celebrations among the travelling fans.
Wrexham found themselves two goals down on 17 minutes when Nathan Turner rounded the defence to cross and brother Lewis was on hand to fire home.
Neil Young's team came under pressure in the second-half, and had to cope with a red card for Ashley Williams, but an uninspired Reds could not crack open the defence.
Wrexham 0 Chester City 0 (September 27, 2009)
One of the more forgettable derbies ended in a stalemate, although Mick Wadsworth's team came closest to sneaking a win.
Clark Keltie was thrown straight into the starting line-up having arrived on loan from Rochdale.
Nick Chadwick had a 'goal' chalked off when referee Michael Naylor ruled Chris Maxwell had been fouled, and Maxwell then made a top class save to push Gregg Blundell's header wide of the post.
Wrexham improved in the second-half but could not find a way through an inspired Blues backline marshalled superbly by captain Tim Ryan.
Chester City 0 Wrexham 2 (March 9, 2008)
Bobby Williamson had been relieved of his duties a week previous and caretaker Simon Davies watched on as goals from Paul Hall and Michael Proctor gave the Reds, who were deep in relegation trouble, a precious three points.
Hall volleyed them ahead on 22 minutes, although seconds before ex-Chester keeper Gavin Ward had punched the ball into his own net only for referee Andy D'Urso to award a free-kick.
Ward pulled off smart saves to keep out Chris Holroyd and Kevin Ellison, and Proctor exposed some slack marking to seal the win in the 65th minute.
Even so, Wrexham still ended the season bottom and were relegated to the Conference Premier, and the Blues would follow them a season later.