WIDNES find themselves second from bottom of the Murray Smith Cheshire County League's Premier Division.
They lost by six wickets at Hyde but enjoyed better fortune in the cups during a hectic first-team weekend.
Shahid Mahboob did well with bat and ball in Friday's Twenty20 Cup win at Warrington, but teenager James McCoy was the hero.
Meanwhile, Sunday's eight-wicket victory from a potentially-tough Cockspur Cup tie against visiting Bramhall sets up a regional-final appearance against Darwen.
Widnes must travel with the likely date being Sunday, June 26.
The Twenty20 derby had seen Widnes amass a massive 190 in their 20 overs.
McCoy plundered 72, including three sixes and six fours, while Cameron Park hit 28 with Phil Catterall and Mahboob each contributing 21.
Valiant Warrington reached 163-9, Mahboob returning 4-33.
In what was always expected to be a difficult game at Hyde on Saturday, Widnes failed to make enough runs on a postage-stamp ground.
McCoy was dismissed for one in the second over. Catterall top-scored with 52 while Steve Titchard (23), Park (29) and Mahboob (18) all chipped in. But none of them dominated.
Tony Hurdley made an assured, unbeaten 35 but the tail failed.
Despite the best efforts of Mahboob, Titchard, Bappa Mukherjee and Sean Moore - and the early loss of Makin - the Tamesiders batted with greater purpose and confidence to win with four overs to spare.
Bramhall arrived at Beaconsfield Road on Sunday as Division One leaders but without Cheshire star Andrew Hall.
Neil Bell (46) and Mike Bolger (77) helped set Widnes a tough victory target of 214 after Hyde had chosen to bat.
Mukherjee took 1-19, Mahboob 1-22. After one over, from which McCoy hit two boundaries, rain intervened.
Seven overs were lost and the Widnes target was reduced to 181.
On the resumption, McCoy blasted five successive boundaries off Bell.
With Titchard joining in the mayhem, Widnes had 50 on the board after four overs.
McCoy departed for 30 off 18 balls but Catterall (48) joined Titchard (85no) in a 96-run partnership which ensured the win.
Widnes will look for a much-needed league victory at home to Chester BH this Saturday.
Tom Evans, 15, followed up his maiden half-century (55no) in Widnes 2nds' draw against Hyde on Saturday by claiming six wickets as the 3rds beat Tattenhall a day later.
Widnes U13s outscored visiting Bootle in the their first Pacific Brands UK Premiership match on Sunday.
In a prolific game of 20 overs per side, more than 300 runs were scored.
Home openers B Williams (82) and J Webb (29) punished any loose ball in a 99-run partnership which took just 13 overs.
Then J Khojani (31no) kept up the momentum, supported by G Yandell in a total of 175-3.
Bootle raced to 89-1 off 10 but tight bowling then restricted them to 141-4 with C Pierce taking 1-18 in four.
Widnes U11s just missed out at Hightown on Wednesday in the LCB Cup.
Hightown finished on 262 net with Widnes 261 net.
On Friday, Widnes hosted Liverpool who elected to bat but were unable to score freely against tight bowling.
They ended on 194 net. In reply, the Widnes batsmen attacked immediately to run out easy winners on 270 net.
This week, the U11s travel to Mossley Hill and Rainhill.
The U13s have a free date and the U15s travel to Sefton Park on Monday before entertaining Wavertree.