PUB and club owners are being warned they could lose their licences if customers' drinks get spiked with date-rape drugs.
Under strict new guidelines being announced today, council chiefs are writing to every pub, club and wine bar warning owners they must do more to protect their customers.
And if they fail it will be considered as a breach of their licensing agreement which may lead to their premises being closed down.
The move will help to ease parents' fears when their children head into the city centre during the festive season.
The council will tell all bars and clubs they must be extra-vigilant and use CCTV cameras to identify possible offenders and victims.
The move, which has the full support of Merseyside Police, comes after tests revealed one in 25 drinks analysed in an Essex night-club were found to contain Rohypnol and GHB.
Coun Malcolm Kelly, chairman of the Licensing Committee, said: "This is the busiest time of the year for clubs and pubs, and so is the most likely time for this illegal practice to take place.
"Spiking drinks by drugs is extremely dangerous and in some cases can prove fatal.
"I am sure most licensees do all they can to prevent this happening but we are reminding them of their responsibilities under their licence.
"If we find that any licensee does not take this issue seriously they would be in breach of their licence and they could have it revoked.
"However, I think they will do what they can to protect their customers."
A campaign is also being run by Citysafe, the part-nership of the council and Merseyside Police, aimed at warning the public of the dangers of spiked drinks.
It will alert the public, especially women, of the dangers of having their drinks spiked and offer advice on how to prevent it happening.
A spokesman for the Lyceum Group, which owns Blue, Pan American and Babycream in the Albert Dock, said: "The Lyceum Group employs a number of measures including CCTV monitoring to protect our guests.
"Table service for food and drink in all our venues provide high standard of personal service and can help to prevent this much-talked-about issue."
Chief Inspector Chris Armitt said: "Compared to other large cities, Liverpool is a very safe place to go out. However, there are a number of very simple steps that can be taken to reduce your risk of becoming a victim of this type of crime."