The M56 has been closed near the Lymm Interchange following a serious collision involving multiple vehicles.
The motorway has been shut in both directions between junctions 9 and 10, causing severe delays.
One man is reported to be trapped in a lorry, according to Cheshire Fire and Rescue Service.
Highways England is predicting that motorists will not experience normal traffic conditions until 8.30pm.
Emergency services are at the scene, and Cheshire police are advising drivers to avoid the area if possible.
North West Motorway Police are urging those stuck in traffic to remain in their vehicles.
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