A man is trapped in a camper van after being involved in a collision on the westbound carriageway of the M56 between junction 14 at Chester and 15 at Hapsford.
Emergency services are currently at the scene of the accident, which has led to the closure of two lanes.
A spokesman for Cheshire Fire and Rescue Service said: "Firefighters are at the scene of a road traffic collision involving a camper van.
"A man is trapped in the vehicle. Crews are stabilising the vehicle so they can remove the casualty safely."
Motorists are advised to approach the area with caution.