A total closure of the M56 between junctions 14 and 11 has been imposed after a tanker overturned near Hapsford shortly before 4pm on Tuesday (October 20).
A cordon has been set up while emergency services deal with the incident, which is causing severe delays and stationary traffic in both directions.
Cheshire Fire and Rescue Service have confirmed that nobody is trapped in the tanker.
Motorist John McDougall reported seeing liquid 'pouring' from the vehicle.
The M56 is currently closed in both directions between junction 11, Daresbury, and Junction 14, Hapsford, due to a one vehicles collision.
Live updates: M56 closed in both directions as tanker overturns
The collision involves a tanker which has overturned on the eastbound carriageway between junction 12 and 14.
Updated: Police say M56 due to reopen around 1am on Wednesday
The driver of the tanker is believed to have suffered minor injuries.
The road is expected to remain closed for several hour and motorists are being advised to avoid the area.
Cheshire Police have declared it a major incident and set up an 1,800m safety cordon around the incident - telling residents in Frodsham and Helsby to stay indoors.
