A total of 53 jobs are at risk in Saltney as Allied Bakeries is planning to close its distribution centre in the town.
The company has told Mark Tami, MP for Alyn and Deeside, that it wants to shut the site in November.
Some staff will be offered the opportunity to relocate to work at their Stockport site.
Allied make well-known bread brands like Kingsmill, Burgen, Allinson and Sunblest.
A consultation process has now started with staff.
Mr Tami said the company was working to keep job losses to a minimum.
He added: “I was very disappointed to hear the news.
"My thoughts are with all the employees during this unsettling time.
"I must commend the representatives of Allied Bakeries for all their efforts to keep the site open, unfortunately it is a very competitive market and now we must focus on offering the employees who will be affected by this the necessary support – something I’m sure they will receive from Allied Bakeries and the relevant bodies.”
An Allied spokeswoman said: "We can confirm that as a result of a detailed review Allied Bakeries has announced a proposal to close our depot on the Chester Road as part of a programme to improve the efficiency of our bread distribution network.
“We are currently consulting with our employees and their Union representatives about these proposals, which if accepted would, regrettably, result in 53 people being placed at risk of redundancy.
“We understand that this will be a difficult and unsettling time for our employees and their families.
"If the proposals are accepted every effort will be made to help those people affected secure alternative employment, either within other parts of Allied Bakeries operations, or externally in the local area, including the wider network of businesses owned by Associated British Foods.
“Our proposals in no way reflect the commitment and efforts of those affected.”