A collision has closed the A49 Tarporley Road this Tuesday afternoon (January 3).
The crash, which involved a Land Rover and a Mercedes, occurred near to the Fox and Barrel pub in Cotebrook at about 3pm.
Cheshire police have closed the busy road at the Sandy Brow lights junction with the A54.
A force spokeswoman said paramedics were attending to check the drivers over.
Motorists are advised to avoid the area.