A man has been taken to hospital after the van he was driving overturned on the A483 Wrexham Road near Eccleston.
The A483 southbound was closed between the Posthouse Roundabout and B5102 for around one hour while emergency services attended the incident, which happened at around 1pm on Thursday.
A spokesman for Cheshire police said: "The incident involved an overturned transit van close to the Eccleston and Pulford junction.
"The male driver was taken to the Countess of Chester Hospital."
North West Ambulance Service sent a rapid response vehicle and road ambulance to the scene.
The road has been cleared and traffic has returned to normal.