In June 2006 Jennifer Metcalfe began playing Mercedes McQueen in the soap Hollyoaks.

In 2007 and 2008, she was nominated for Sexiest Female at both the British Soap Awards and the Inside Soap Awards for her role as Mercedes, along with John Cooper who won Sexiest Male for his role in The Street.

Before Hollyoaks, she appeared in several TV shows including kids' TV series My Parents Are Aliens and ITV dramas Where The Heart Is and At Home with the Braithwaites, as well as Yorkshire soap Emmerdale.

In between acting jobs Metcalfe worked as a fitness instructor in Bradford.

She co-owns clothing rental boutique The Closet in Liverpool with Hollyoaks co-stars Claire Cooper and Leah Hackett, which opened in April 2010.