Emergency and urgent care at the Countess of Chester Hospital will still be provided as junior doctors are set to strike again over contracts.
Some outpatient appointments have been cancelled before the 24-hour walkout from 8am on Wednesday (February 10).
Anyone affected should already have been notified.
British Medical Association members are protesting after another breakdown in talks with Health Secretary Jeremy Hunt.
A West Cheshire CCG spokesman said: “Clinical teams and managers will work closely to ensure that any disruption does not put patient welfare or safety at risk, but routine hospital appointments or procedures are likely to experience significant disruption or rescheduling.
“Anyone affected will be contacted by the hospital.
“The NHS in West Cheshire is asking people to continue to make full use of its other services - including GP practices, walk-in centres, pharmacies and the 111 phone line.”
This action mirrors the walkout taken by junior doctors across the country on January 13.
Since then negotiations have continued over the deal, but a dispute remains over changes to unsocial hours which could result in many doctors seeing a reduction in their pay.
A&E departments will remain open during the strike, but most surgeries which are not life-threatening cases will also be cancelled.
Some doctors from the Countess and Alder Hey Children's Hospital are planning to teach basic life support skills at the Cheshire Cat in Christleton in the afternoon on Wednesday.
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BMA junior doctors committee chair Johann Malawana said: “The Government’s entrenched position in refusing to recognise Saturday working as unsocial hours, together with its continued threat to impose a contract so fiercely resisted by junior doctors across England, leaves us with no alternative but to continue with industrial action.
“The Government misrepresents junior doctors as a block to a seven-day NHS, but they already work every day of the week.
“What we are asking is that this is reflected in fair and affordable recognition of unsocial hours.”
What you need to know
Rather than making A&E the first port of call, those suffering from minor ailments are advised to visit their local pharmacist, contact the NHS 111 telephone service or consult your GP.
For patients with urgent healthcare needs, the GP Out of Hours service is available in West Cheshire after 6.30pm on weekdays, at weekends and Bank Holidays by calling 01244 385300.
More information is available on the Countess of Chester website.
What do you think of this story? Do you support the industrial action? Let us know in the comments below.