A £1m appeal to build a new cancer treatment centre at Leighton Hospital will be officially launched on Monday.
Civic dignitaries, business people and representatives from organisations will take part in a Champagne launch aboard the Northern Belle train at Crewe Station.
Macmillan Cancer Support wants to build a state-of-the-art facility at the Crewe hospital where lack of space has seen patients receiving chemotherapy in corridors.
Charity director Maureen Rutter said: 'The launch is sponsored by the Orient Express company and is designed to get the support of key people from Crewe.
'We have invited cancer patients who will explain what it is like to have treatment in cramped, inconvenient surroundings. We will explain what the new unit will offer and how it will make life so much better for both staff and patients.'
The cost of the centre will be split between the Mid-Cheshire Hospitals Trust, which runs Leighton, Macmillan and a fundraising drive in the community.